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Journal Club Date Articles Topic
December 2019 Physical Activity and Risk of Postoperative Delirium. J Am Geriatr Soc. 2019 Nov;67(11):2260-2266. PUBMED: 31368511   delirium  YouTube archive
December 2019 Association Between Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical Hypothyroidism. JAMA. 2019 Oct 30:1-11.  [Epub ahead of print] PUBMED: 31664429  hypothyroidism  YouTube archive
November 2019 Individualised nutritional support in medical inpatients at nutritional risk: a randomised clinical trial. Lancet. 2019 Jun 8;393(10188):2312-2321. PMID: 31030981 nutrition  YouTube archive
October 2019 Impact of Social Network on the Risk and Consequences of Injurious Falls in Older Adults. J Am Geriatr Soc. 2019 Sep;67(9):1851-1858. PMID: 31241183 falls  YouTube archive
October 2019 Is the association between blood pressure and mortality in older adults different with frailty? A systematic review and meta-analysis. Age Ageing. 2019 Jun 5.[Epub ahead of print] PMID: 31165151 frailty  YouTube archive
September 2019 CPAP Adherence May Slow 1-Year Cognitive Decline in Older Adults with Mild Cognitive Impairment and Apnea. J Am Geriatr Soc. 2019 Mar;67(3):558-564. PMID: 30724333 mild cognitive impairment  YouTube archive
September 2019 Associations of Amyloid, Tau, and Neurodegeneration Biomarker Profiles With Rates of Memory Decline Among Individuals Without Dementia. JAMA. 2019 Jun 18;321(23):2316-2325. PMID: 31211344 dementia  YouTube archive
August 2019 Clinical Significance of Magnetic Resonance Imaging Markers of Vascular Brain Injury: A Systematic Review and Meta-analysis. JAMA Neurol. 2019 Jan 1;76(1):81-94. PMID: 30422209 vascular cognitive impairment YouTube archive
August 2019 Scam Awareness Related to Incident Alzheimer Dementia and Mild Cognitive Impairment: A Prospective Cohort Study. Ann Intern Med. 2019 May 21;170(10):702-709. PMID: 30986826 dementia YouTube archive
July 2019 Association of Delirium Response and Safety of Pharmacological Interventions for the Management and Prevention of Delirium: A Network Meta-analysis. JAMA Psychiatry. 2019 May 1;76(5):526-535. PMID: 30810723 delirium YouTube archive
May 2019 Effects of a Primary Care-Based Multifactorial Intervention on Physical and Cognitive Function in Frail, Elderly Individuals: A Randomized Controlled Trial. J Gerontol A Biol Sci Med Sci. 2018 Nov 10;73(12):1688-1674. PMID: 29346524 frailty
May 2019 Transcatheter Aortic-Valve Replacement with a Self-Expanding Valve in Low-Risk Patients. N Engl J Med. 2019 May 2;380(18):1706-1715. PMID: 30883053 TAVR
April 2019 Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical Trial. JAMA. 2019 Feb 12;321(6):553-561. PMID: 30688979 hypertension YouTube archive
April 2019 Randomized Delayed-Start Trial of Levodopa in Parkinson’s Disease. N Engl J Med. 2019 Jan 24;380(4):315-324. PMID: 30673543 parkinson’s YouTube archive
March 2019 Efficacy and safety of statin therapy in older people: a meta-analysis of individual participant data from 28 randomised controlled trials. Lancet. 2019 Feb 2;393(10170):407-415. PMID: 30712900  statins YouTube archive
February 2019 Comparative risk of harm associated with trazodone or atypical antipsychotic use in older adults with dementia: a retrospective cohort study. CMAJ. 2018 Nov 26;190(47):E1376-E1383. PMID: 30478215 dementia  YouTube archive
January 2019 Watt JA, Gomes T, Bronskill SE, Huang A, Austin PC, Ho JM, Straus SE. Comparative risk of harm associated with trazodone or atypical antipsychotic use in older adults with dementia: a retrospective cohort study. CMAJ. 2018 Nov 26;190(47):E1376-E1383. doi: 10.1503/cmaj.180551. [article link] dementia YouTube archive
December 2018 Fracture Prevention with Zoledronate in Older Women with Osteopenia. NEJM 2018 [ePub ahead of print] [article link]  osteoporosis YouTube archive
December 2018 Effect of Exercise Intervention on Functional Decline in Very Elderly Patients During Acute Hospitalization: A Randomized Clinical Trial. JAMA Intern Med. 2018 Nov 12. [Epub ahead of print] [article link] functional decline YouTube archive
November 2018 MEMO+: Efficacy, Durability and Effect of Cognitive Training and Psychosocial Intervention in Individuals with Mild Cognitive Impairment. J Am Geriatr Soc. 2018 Apr;66(4):655-663. [article link] mild cognitive impairment
November 2018 Higher Quality, Lower Cost with an Innovative Geriatrics Consultation Service. J Am Geriatr Soc. 2018 Sep;66(9):1790-1795. [article link] models of care
October 2018 Effect of Aspirin on All-Cause Mortality in the Healthy Elderly. N Engl J Med. 2018 Oct 18;379(16):1519-1528. doi: 10.1056/NEJMoa1803955. primary prevention YouTube archive
October 2018 Effect of Depth of Sedation in Older Patients Undergoing Hip Fracture Repair on Postoperative Delirium: The STRIDE Randomized Clinical Trial. JAMA Surg. 2018 Aug 8. [Epub ahead of print] delirium YouTube archive
September 28 2018 Estimation of lifetime risks of Alzheimer’s disease dementia using biomarkers for preclinical disease. Alzheimers Dement. 2018 Aug;14(8):981-988.  PMID: 29802030  dementia  YouTube archive
 August 2018 Use of haloperidol versus atypical antipsychotics and risk of in-hospital death in patients with acute myocardial infarction: cohort study. BMJ 2018;360:k1218  antipsychotics  YouTube archive
 August 2018 Acetylcholinesterase inhibitors and risk of stroke and death in people with dementia. Alzheimers Dement. 2018 Jul;14(7):944-951.  dementia  YouTube archive
July 2018 Dementia And Physical Activity (DAPA) trial of moderate to high intensity exercise training for people with dementia: randomised controlled trial. BMJ 2018;361:k1675 dementia YouTube archive
July 2018 Antipsychotic Deprescription for Older Adults in Long-term Care: The HALT Study. J Am Med Dir Assoc. 2018 Jul;19(7):592-600.e7. PMID: 29941156 BPSD YouTube archive
May 2018 Medicaid Cost Savings of a Preventive Home Visit Program for Disabled Older Adults. J Am Geriatr Soc. 2018 Mar;66(3):614-620. PMID: 29165789 home visits YouTube archive
May 2018 Evaluation of the safety, tolerability, and efficacy of pimavanserin versus placebo in patients with Alzheimer’s disease psychosis: a phase 2, randomised, placebo-controlled, double-blind study. Lancet Neurol. 2018 Mar;17(3):213-222. PMID: 29452684 dementia YouTube archive
April 2018 Impact of Age on Pain Perception for Typical Painful Diagnoses in the Emergency Department. J Emerg Med. 2016 Jan;50(1):14-20. PMID:26416133 pain  YouTube archive
April 2018  Clinical and cognitive trajectories in cognitively healthy elderly individuals with suspected non-Alzheimer’s disease pathophysiology (SNAP) or Alzheimer’s disease pathology: a longitudinal study. Lancet Neurol 2016; 15: 1044–53. PMID:27450471 cognitive impairment  YouTube archive
April 2018  Age and gender variations of sleep in subjects without sleep disorders. Annals of Medicine, 2015; 47: 482–491. PMID:26224201 sleep  YouTube archive
March 2018 Adjunct zonisamide to levodopa for DLB parkinsonism: A randomized double-blind phase 2 study. Neurology. 2018 Feb 20;90(8):e664-e672. PMID:29367449 parkinsonism YouTube archive
February 2018 DHA supplementation improves cognitive function via enhancing Aβ-mediated autophagy in Chinese elderly with mild cognitive impairment: a randomised placebo-controlled trial. J Neurol Neurosurg Psychiatry. 2017 Nov 15. PMID: 29142143 cognition  YouTube archive
February 2018 Association Between Purpose in Life and Objective Measures of Physical Function in Older Adults. JAMA Psychiatry. 2017 Oct 1;74(10):1039-1045. PMID: 28813554 physical function YouTube archive
January 2018 Methylphenidate for Apathy in Community-Dwelling Older Veterans With Mild Alzheimer’s Disease: A Double-Blind, Randomized, Placebo-Controlled Trial. Am J Psychiatry. 2017 [Epub ahead of print] PMID: 28945120 BPSD Youtube archive
January 2018 Personal Sound Amplification Products vs a Conventional Hearing Aid for Speech Understanding in Noise. JAMA. 2017 Jul 4;318(1):89-90. PMID: 28672306 hearing Youtube archive
December 2017 Reliable adherence to a COPD care bundle mitigates system-level failures and reduces COPD readmissions: a system redesign using improvement science. BMJ Qual Saf. 2017 Nov;26(11):908-918.  PMID: 28733370 improvement science
November 2017 Protein Intake and Mobility Limitation in Community-Dwelling Older Adults: the Health ABC Study. J Am Geriatr Soc. 2017 Aug;65(8):1705-1711. PMID: 28306154 mobility
October 2017 Romosozumab or Alendronate for Fracture Prevention in Women with Osteoporosis. N Engl J Med. 2017 Oct 12;377(15):1417-1427. PMID: 28892457 osteoporosis
September 2017 Association of a Communication Training Program With Use of Antipsychotics in Nursing Homes. JAMA Intern Med. 2017 Jun 1;177(6):846-853. PMID: 28418449 dementia
September 2017 Treatment of Sarcopenia with Bimagrumab: Results from a Phase II, Randomized, Controlled, Proof-of-Concept Study. J Am Geriatr Soc. 2017 Sep;65(9):1988-1995. PMID: 28653345 sarcopenia
Associations of acetylcholinesterase inhibitor treatment with reduced mortality in Alzheimer’s disease: a retrospective survival analysis. Age Ageing. 2017 Jun 24:1-7. PMID: 28655175 dementia
August 2017 Aerobic or Resistance Exercise, or Both, in Dieting Obese Older Adults. N Engl J Med. 2017 May 18;376(20):1943-1955. PMID: 28514618 frailty Download transcript
July 2017 Medical Directive for Urinary Catheter Removal by Nurses on General Medical Wards. PMID: 26571234 continence Download transcript
July 2017 Effect of a Modified Hospital Elder Life Program on Delirium and Length of Hospital Stay in Patients Undergoing Abdominal Surgery: A Cluster Randomized Clinical Trial. JAMA Surg. 2017 [ahead of print] PMID: 28538964 delirium Download transcript
May 2017 Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism. N Engl J Med. 2017  [Epub ahead of print] PMID: 28402245 hypothyroidism Download transcript
March 2017 What paint can tell us: A fractal analysis of neurological changes in seven artists. Neuropsychology. 2017 Jan;31(1):1-10. PMID: 28026197 neurodegenerative disorders Download transcript
March 2017 Effect of Abaloparatide vs Placebo on New Vertebral Fractures in Postmenopausal Women With Osteoporosis: A Randomized Clinical Trial. JAMA. 2016 Aug 16;316(7):722-33.  PMID: 27533157script osteoporosis Download transcript
February 2017 Effects of Testosterone Treatment in Older Men. N Engl J Med. 2016 Feb 18;374(7):611-24. PMID:26886521 Testosterone Download transcript
January 2017 The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease. Nature. 2016 Sep 1;537(7618):50-6. PMID: 27582220 Dementia Download transcript
November 2016 Effectiveness of medication withdrawal in older fallers: results from the Improving Medication Prescribing to reduce Risk Of FALLs (IMPROveFALL) trial. Age Ageing. 2016 Sep 10. PMID: 27614080  Falls Download transcript
November 2016 Elder-Clowning in Long-Term Dementia Care: Results of a Pilot Study. J Am Geriatr Soc. 2016 Feb;64(2):347-53. PMID: 26889843  Dementia Download transcript
October 2016 Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery. N Engl J Med. 2010 Oct 21;363(17):1597-607. PMID: 20961243  Aortic stenosis Download transcript
October 2016 Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trial. Lancet. 2016 Oct 15;388(10054):1893-1902. PMID: 27542303 Delirium Download transcript
September 2016 Effectiveness of two year balance training programme on prevention of fall induced injuries in at risk women aged 75-85 living in community: Ossébo randomised controlled trial. BMJ. 2015 Jul 22;351:h3830.
PMID: 26201510
Falls Download transcript
August 2016 Comparison of Posthospitalization Function and Community Mobility in Hospital Mobility Program and Usual Care Patients: A Randomized Clinical Trial. JAMA Intern Med. 2016 Jul 1;176(7):921-7. PMID: 27243899 Functional decline Download transcript
August 2016 Fascia iliaca block prophylaxis for hip fracture patients at risk for delirium: a randomized placebo-controlled study.
J Orthop Traumatol. 2009 Sep;10(3):127-33. PMID: 2744739
Hip fracture


Download transcript
July 2016 Citalopram, methylphenidate, or their combination in geriatric depression: a randomized, double-blind, placebo-controlled trial. PMID: 25677354 Depression Download transcript
July 2016 Association Between Anticholinergic Medication Use and Cognition, Brain Metabolism, and Brain Atrophy in Cognitively Normal Older Adults. JAMA Neurol. 2016 [ahead of print].
PMID: 27088965
Cognitive impairment Download transcript
April 2016 Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis. Lancet. 2016 [Epub ahead of print]. PMID: 26997557  Osteoarthritis Download transcript
March 2016 Monthly High-Dose Vitamin D Treatment for the Prevention of Functional Decline: A Randomized Clinical Trial. JAMA Intern Med. 2016 Feb 1;176(2):175-83.  PMID: 26747333 Functional decline Download transcript
March 2016 Invasive versus conservative strategy in patients aged 80 years or older with non-ST-elevation myocardial infarction or unstable angina pectoris (After Eighty study): an open-label randomised controlled trial.Lancet. 2016 Jan 12.  [Epub ahead of print]. PMID: 26794722 Cardiac disease Download transcript
February 2016 A Randomized, Controlled Trial of Total Knee Replacement. N Engl J Med. 2015 Oct 22;373(17):1597-606. PMID: 26488691 Osteoarthritis Download transcript
February 2016 Comprehensive geriatric assessment on an acute medical unit: A qualitative study of older people’s and informal carer’s perspectives of the care and treatment received. Clin Rehabil. 2016 Jan 22. [Epub ahead of print] PMID: 26801585 CGA Download transcript
January 2016  A Randomized Trial of Intensive versus Standard Blood-Pressure Control. N Engl J Med. 2015 Nov 26;373(22):2103-16. PMID: 26551272 Hypertension Download transcript
January 2016 Nutritional, Physical, Cognitive, and Combination Interventions and Frailty Reversal Among Older Adults: A Randomized Controlled Trial. Am J Med. 2015 Nov;128(11):1225-1236. PMID: 26159634  Frailty Download transcript
December 2015  Effect of Discontinuation of Antihypertensive Treatment in Elderly People on Cognitive Functioning-the DANTE Study Leiden: A Randomized Clinical Trial. JAMA Intern Med. 2015 Oct 1;175(10):1622-30. PMID: 26301603 Cognitive Impairment Download transcript
December 2015 Practical problems with medication use that older people experience: a qualitative study. J Am Geriatr Soc. 2014 Dec;62(12):2339-44. PMID: 25516030 Polypharmacy Download transcript
November 2015 Effect of Dextromethorphan-Quinidine on Agitation in Patients With Alzheimer Disease Dementia: A Randomized Clinical Trial. JAMA. 2015 Sep 22-29;314(12):1242-54. PMID: 26393847 Dementia Download transcript
October 2015 Medical students’ and doctors’ attitudes towards older patients and their care in hospital settings: a conceptualisation. Age Ageing. 2015 Sep;44(5):776-83. PMID: 26185282 Medical Education Download transcript

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October 2015 Comprehensive geriatric care for patients with hip fractures: a prospective, randomised, controlled trial. Lancet. 2015 Apr 25;385(9978):1623-33. PMID:25662415 Hip Fracture Download transcript

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September 2015 Effects of low blood pressure in cognitively impaired elderly patients treated with antihypertensive drugs. JAMA Intern Med. 2015 Apr;175(4):57885. PMID:25730775 Cognitive Impairment Download transcript

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August 2015 Efficacy of an adjuvanted herpes zoster subunit vaccine in older adults. N Engl J Med. 2015 May 28;372(22):2087-96. PMID: 25916341 Herpes Zoster Download transcript
August 2015 Delayed-start analysis: Mild Alzheimer’s disease patients in solanezumab trials, 3.5 years. Alzheimer’s & Dementia: Translational Research & Clinical Interventions. 2015; 111-121. Link Dementia Download transcript
July 2015 Safety and benefit of discontinuing statin therapy in the setting of advanced, life-limiting illness: a randomized clinical trial. JAMA Intern Med. 2015 May;175(5):691-700. PMID: 25798575 Polypharmacy Download transcript
July 2015 A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet. 2015 Jun 6;385(9984):2255-63.PMID: 25771249 Cognitive Impairment Download transcript
May 2015 Mindfulness meditation and improvement in sleep quality and daytime impairment among older adults with sleep disturbances: a randomized clinical trial. JAMA Intern Med. 2015 Apr 1;175(4):494-501. PMID: 25686304 Sleep Download transcript
May 2015 Risk factors and screening instruments to predict adverse outcomes for undifferentiated older emergency department patients: a systematic review and meta-analysis. Acad Emerg Med. 2015 Jan;22(1):1-21. PMID: 25565487 Geriatric Emergency Download transcript
April 2015 Nonpharmacologic management of orthostatic hypotension: a systematic review. Arch Phys Med Rehabil. 2015 Feb;96(2):366-375. PMID: 25449193 Orthostatic Hypotension Download transcript
March 2015 American Geriatrics Society abstracted clinical practice guideline for postoperative delirium in older adults. J Am Geriatr Soc. 2015 Jan;63(1):142-50. PMID: 25495432 Delirium Download transcript
March 2015 Droxidopa for neurogenic orthostatic hypotension: a randomized, placebo-controlled, phase 3 trial. Neurology. 2014 Jul 22;83(4):328-35. PMID: 24944260 Orthostatic Hypotension Download transcript
February 2015 Home modifications to reduce injuries from falls in the Home Injury Prevention Intervention (HIPI) study: a cluster-randomised controlled trial. The Lancet, Volume 385, Issue 9964, 17–23 January 2015, Pages 231-238. PMID: 25255696 Falls Download transcript
January 2015 Problem adaptation therapy for older adults with major depression and cognitive impairment: a randomized clinical trial. JAMA Psychiatry. 2015 Jan 1;72(1):22-30. PMID: 25372657 Depression Download transcript
January 2015


Fracture prediction after discontinuation of 4 to 5 years of alendronate therapy: the FLEX study. JAMA Intern Med. 2014 Jul;174(7):1126-34. PMID: 24798675 Osteoporosis Download transcript
December 2014 Pre-operative indicators for mortality following hip fracture surgery: a systematic review and meta-analysis. Age Ageing. 2014 Jul;43(4):464-71. PMID: 24895018 Hip Fracture Download transcript
December 2014 Intervention with the screening tool of older persons potentially inappropriate prescriptions/screening tool to alert doctors to right treatment criteria in elderly residents of a chronic geriatric facility: a randomized clinical trial. J Am Geriatr Soc. 2014 Sep;62(9):1658-65. PMID: 25243680 Polypharmacy Download transcript
November 2014 3D-CAM: Derivation and Validation of a 3-Minute Diagnostic Interview for CAM-Defined Delirium: A Cross-sectional Diagnostic Test Study. Ann Intern Med. 2014 Oct 21;161(8):554-61. PMID: 25329203 Delirium Download transcript
November 2014 Osteoporotic Fractures in Men Study Group. Implications of expanding indications for drug treatment to prevent fracture in older men in United States: cross sectional and longitudinal analysis of prospective cohort study. BMJ. 2014 Jul 3;349:g4120. PMID: 24994809 Osteoporosis Download transcript
October 2014 Effect of melatonin on incidence of delirium among patients with hip fracture: a multicentre, double-blind randomized controlled trial. CMAJ. 2014 Oct 7;186(14):E547-56. PMID: 25183726 Delirium, Hip Fracture Download transcript
October 2014 Effect of Physical Therapy on Pain and Function in Patients With Hip Osteoarthritis. A Randomized Clinical Trial JAMA. 2014;311(19):1987-1997.PMID: 24846036 Physiotherapy, Osteoarthritis Download transcript
September 2014 Atypical Antipsychotic Drugs and the Risk for Acute Kidney Injury and Other Adverse Outcomes in Older Adults.  Ann Intern Med.2014;161:242-248. PMID: 25133360 Antipsychotics Download transcript
September 2014 The efficacy and tolerability of the b3-adrenoceptor agonist Mirabegron for the treatment of symptoms of overactive bladder in older patients. Age and Ageing 2014;43:666–675. PMID: 24610862 Incontinence Download transcript
August 2014 The CAM-S: development and validation of a new scoring system for delirium severity in 2 cohorts. Ann Intern Med. 2014 Apr 15;160(8):526-33. PMID: 24733193 Delirium Download transcript
August 2014 Multidimensional Frailty Score for the Prediction of Postoperative Mortality Risk. JAMA Surg. 2014;149(7):633-640. PMID: 24804971 Frailty Download transcript


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